Medical safety and limitations
Do not use this estimate alone to diagnose a calcium disorder or start, stop, or change treatment. Albumin correction formulas can misclassify low, normal, and high calcium status. Their performance varies with the patient population, albumin and calcium assays, kidney function, critical illness, pH, phosphate, and other factors.
Use the method and reference interval supplied by the laboratory. When the distinction is clinically important—especially with symptoms, markedly abnormal results, severe hypoalbuminemia, critical illness, or kidney disease—a clinician may use a directly measured ionized calcium result and other tests rather than this estimate.
